Tag Archives: SARS-CoV-2 vaccines

Can We Just Admit We Don’t Have The Answer Yet?

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On Friday, The Epoch Times posted an article about the effectiveness of the Covid-19 booster shots.

The article reports:

The effectiveness of COVID-19 vaccine booster doses dropped well under 50 percent after four months against subvariants of the virus that causes COVID-19, according to a new study from the U.S. Centers for Disease Control and Prevention (CDC).

The Moderna and Pfizer vaccines provided just 51 percent protection against emergency department visits, urgent care encounters, and hospitalizations related to COVID-19 during the time BA.2 and BA.2.12.1, subvariants of the Omicron virus variant, were predominant in the United States, CDC researchers found.

Both vaccines are administered in two-dose primary series.

After 150-plus days, the effectiveness dropped to just 12 percent.

A first booster upped the protection to 56 percent, but the effectiveness went down to 26 percent after four months, according to the study, which drew numbers from a network of hospitals funded by the CDC across 10 states called the VISION Network.

The subvariant was predominant between late March and mid-June.

The article also notes:

Underlining the waning effectiveness against severe illness, the majority of patients admitted to the hospitals between December 2021 and June 2022 had received at least two doses of the vaccines.

Further, the percentage of unvaccinated patients dropped during the later period, going from 41.6 percent to 28.6 percent (hospitalized patients) and from 41.4 percent to 31 percent (emergency department and urgent care patients), researchers found.

The researchers, some of whom work for the CDC, theorized that the protection—known as natural immunity—many unvaccinated people enjoy from having had COVID-19 could be a factor in the drop in effectiveness of the vaccines, even though adults with documented prior infection were excluded from the study.

“If unvaccinated persons were more likely to have experienced recent infection, and infection-induced immunity provides some protection against re-infection, this could result in lower VE observed during the BA.2/BA.2.12.1 period,” they wrote. VE stands for vaccine effectiveness.

“Although adults with documented past SARS-CoV-2 infection were excluded, infections are likely to be significantly underascertained because of lack of testing or increased at-home testing. In addition, although time since receipt of the second or third vaccine dose was stratified by time intervals, on average the time since vaccination was longer during the BA.2/BA.2.12.1 period,” they added.

Although the medical community recommends flu shots every year, they also admit that predicting the particular variant of the flu that will be present during that flu season is something of a crap shoot. It seems that we are having the same problem with Covid-19, also a virus. I suspect coming up with a truly effective vaccine against Covid infections is probably about as likely as coming up with a vaccine for the common cold. I think we still have a lot to learn.

More Questions Than Answers

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There are two things that puzzle me about the insistence that all Americans be vaccinated against Covid-19. The first is the lack of emphasis on the methods of treatment that have proven to be successful–Hydroxychloroquine and Azithromycin, Ivermectin, Resveratrol, etc. Various combinations of these substances have been proven effective in treating even severe Covid-19 cases. The second thing that puzzles me is the total ignoring of the concept of immunity due to having recovered from the disease.

Yesterday The Epoch Times posted an article about a new study of Covid-19 cases and those who have recovered from the disease.

The article reports:

People who have recovered from COVID-19 retain broad and effective longer-term immunity to the disease, according to a new study.

Findings of the study, which is the most comprehensive of its kind so far, have implications for expanding understanding about human immune memory as well as future vaccine development for coronaviruses.

For the longitudinal study in Cell Reports Medicine, researchers looked at 254 patients with mostly mild to moderate symptoms of SARS-CoV-2 infection over a period of more than eight months (250 days) and found that their immune response to the virus remained durable and strong.

The findings are reassuring, especially given early reports during the pandemic that protective neutralizing antibodies didn’t last in COVID-19 patients, said Rafi Ahmed, director of the Emory University Vaccine Center and a lead author of the paper.

“The study serves as a framework to define and predict long-lived immunity to SARS-CoV-2 after natural infection. We also saw indications in this phase that natural immunity could continue to persist,” Ahmed said.

The research team will continue to evaluate this cohort over the next few years.

The article notes:

In following the patients for months, researchers got a more nuanced view of how the immune system responds to COVID-19 infection. The picture that emerges indicates that the body’s defense shield not only produces an array of neutralizing antibodies but activates certain T and B cells to establish immune memory, offering more sustained defenses against reinfection.

…Ahmed said investigators were surprised to see that convalescent participants also displayed increased immunity against common human coronaviruses as well as SARS-CoV-1, a close relative of the current coronavirus. The study suggests that patients who survived COVID-19 are likely to also possess protective immunity even against some SARS-CoV-2 variants.

“Vaccines that target other parts of the virus rather than just the spike protein may be more helpful in containing infection as SARS-CoV-2 variants overtake the prevailing strains,” Ahmed said. “This could pave the way for us to design vaccines that address multiple coronaviruses.”

The researchers said the study more comprehensively identifies the adaptive immune components leading to recovery, and that it will serve as a benchmark for immune memory induced by SARS-CoV-2 vaccines.

This is good news.